By A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)
Over the prior decade loads of examine job has happened on each side of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal security and the way those should be compromised in peptic ulcer sickness. a first-rate stimulus to such study has been the conclusion that irregular acid secretion or its supply into the duodenum in over the top volume can't absolutely clarify ulcer pathogenesis within the majority of sufferers. One may perhaps envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal elements, resembling acid and pepsin, being counteracted through protecting mucosal mechanisms. until eventually lately, the mechanisms excited about mucosal safety have been poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion were elucidated. The influence that gastroduodenal mucosa was once safe by way of a unmarried mechanism has ultimately been changed by way of a extra sensible view, suggesting a few protecting zones appearing in sequence. a few of these zones may well act as first or moment line defences opposed to competitive elements whereas definite zones could particularly defend opposed to sure aggressors.
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Additional resources for Advances in Peptic Ulcer Pathogenesis
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Advances in Peptic Ulcer Pathogenesis by A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)