Download e-book for iPad: Activation of Hormone and Growth Factor Receptors: Molecular by M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis,

By M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis, Prof. Constantin E. Sekeris (eds.)

ISBN-10: 9400919360

ISBN-13: 9789400919365

ISBN-10: 9401073643

ISBN-13: 9789401073646

This quantity includes the papers awarded within the NATO complex learn Workshop "Activation of Hormone and development issue Receptors: Molecular Mechanisms and results" held in Nafplion, Greece on September 25-30, 1988. the target of NATO ARW is to evaluate the kingdom of-the-art in a given clinical sector and to formulate strategies for destiny examine in rising components of technological know-how by way of selling overseas medical contacts. within the Nafplion assembly this target used to be reached by way of a world crew of audio system, senior Greek scientists and graduates inquisitive about correct study parts. The Workshop used to be made attainable by way of the beneficiant aid of the clinical Council of NATO. We thank Drs. G. Sinclair and L.V. daCunha, administrators of the NATO ARW's and ASI's (Advanced learn Institutes) respectively, for his or her wholehearted help and suggestion. The foreign Union of Biochemistry offered extra go back and forth delivers resulting in elevated overseas participation. in addition, the Secretariat of technological know-how and know-how, the Ministry of tradition and Sciences and the nationwide Hellenic study origin contributed financially and through aiding team of workers. We truly thank some of these agencies for his or her aid. Our heartful thank you also are prolonged to the Mayor of the Municipality of Nafplion, Mr.

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Additional resources for Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences

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Inappropriate expression of the cellular counterparts of viral oncogenes is thought to be responsible for the initiation' and maintenance of malignant growth. Therefore, the study of the mode of action of growth factors will undoubtedly yield important insight into the mechanisms underlying carcinogenesis. Signal pathways in growth factor action Understanding the mode of action of growth factors requires the identification of intracellular signals that are essential for the stimulation of DNA synthesis and cell division.

Ali gnment of the protei n sequences of the 5 members of the FGF family reveals similar gene structures, with conservation of both the location and type of intron junction (within or interrupti ng a codon). In contrast to aFGF and bFGF. i nt-2, hst, and FGF-5 all possess amino terminal hydrophobic signal peptide-like sequences whi ch di rect protei n secret; on. The ami no aci d sequence identities and the common gene structure amongst the 5 members of the FGF protei n fami 1y c 1earl y i ndi ca te that they are deri ved from a common ancestral gene.

This apparent desensitization of the response is not observed with EGF as a stimulus (Tilly et aI, manuscript submitted). In general, the brarlykinindependent pattern of stimulation is significantly different from that observed in EGF-stimulated A431 cells, suggesting that there are separate mechanisms of inositol lipid hydrolysis involved. A hitherto unrecognized growth factor is histamine, which stimulates the growth of human HeLa cells cells by activating the Ca 2+ -mobilizing HI receptor (Tilly et aI, manuscript in preparation).

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Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences by M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis, Prof. Constantin E. Sekeris (eds.)


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