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However, patients who had developed macrovascular disease at the time of baseline examination had a lower retinopathy incidence. The authors state that this may be due to the fact that 68% of the patients who had macrovascular disease either died (54%) during the follow-up period or were lost to follow-up (14%). Many of these patients may have developed retinopathy, particularly the patients who have died, but were not included. Therefore, the lower incidence of retinopathy in patients who had macrovascular disease at baseline is probably the result of a selection bias.

1993). The mean [standard deviation (SD)] age and duration of diabetes at baseline examination were 52 (11) and 7 (6) years. The average duration of follow-up was 10 (SD 4) years. As of December 31, 1989, 548 patients were alive, 452 (187 men and 265 women) were dead, and 12 could not be traced. 6 gives the survival time in years (T ) of the ﬁrst 40 male patients along with 12 potential prognostic factors: age, duration of diabetes (DUR) in years, family history of diabetes (FAM), use of insulin within one year of diagnosis (INS), use of diuretics (DIU), hypertension (HBP), retinopathy (EVD), proteinuria (PRO), fasting plasma glucose (GLU) in milligrams per deciliter, cholesterol (TC) in milligrams per deciliter, triglyceride (TG) in milligrams per deciliter, and body mass index (BMI), which is deﬁned as weight in kilograms divided by height in meters squared.

1971). 3: FITTING SURVIVAL DISTRIBUTIONS TO REMISSION DATA The remission times of 42 patients with acute leukemia were reported by Freireich et al. Each patient was randomized to receive 6-MP or a placebo. The study was terminated after one year. The following remission times, in weeks, were recorded: 6-MP (21 patients): 6, 6, 6, 7, 10, 13, 16, 22, 23, 6;, 9;, 10;, 11;, 17;, 19;, 20;, 25;, 32;, 32;, 34;, 35; Placebo (21 patients): 1, 1, 2, 2, 3, 4, 4, 5, 5, 8, 8, 8, 8, 11, 11, 12, 12, 15, 17, 22, 23 Suppose that we are interested in a distribution to describe the remission times of these patients but that no information is available as to which distribution will ﬁt.

### 50 Jahre Deutsche Statistische Gesellschaft Tagungen 1961 und 1962

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